Blar i forfatter "Scott, John D."

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    • Protein kinase A opposes the phosphorylation-dependent recruitment of glycogen synthase kinase 3β to A-kinase Anchoring Protein 220 

      Whiting, Jennifer L.; Nygren, Patrick J.; Tunquist, Brian J.; Langeberg, Lorene K.; Seternes, Ole Morten; Scott, John D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-18)
      The proximity of an enzyme to its substrate can influence rate and magnitude of catalysis. A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes. These include protein kinase A (PKA) and glycogen synthase kinase 3 (GSK3). Using a combination of molecular and cellular approaches we show that GSK3 phosphorylation of ...